Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC009
Sex MALE
Dominant hand LEFT
Test date and time 2022-02-23 09:55
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar a 250mg 3x1/4 tbl Mirapexin a 4mg 1 ujutru tbl Nemdatine a 10mg 1 ujutru

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 25 individuals with a value less than 0.6 were subsequently diagnosed with PD. That is, 59.52% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.6 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 20, 'TN': 15, 'TP': 22, 'FP': 15}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 42, 'TN': 30, 'TP': 0, 'FP': 0}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 20, 'TN': 10, 'TP': 22, 'FP': 20}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 28, 'TN': 19, 'TP': 14, 'FP': 11}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 10.116
timePerCircleCoV 0.145278
timePerCircleSlope -0.0173742
meanError 1.53605
tremorFreq 5.46875
tremorRelPower 48.6922
tremorGyroAmpMean 0.0390595
tremorGyroAmpSlope -0.0211758
tremorGyroAmpCoV 1.75757
tremorCoordAmpMean 0.125414
tremorCoordAmpSlope -0.0177342
tremorCoordAmpCoV 1.91579
tremorAccAmpMean 0.113375
tremorAccAmpSlope -0.0235528
tremorAccAmpCoV 2.16023
tremorPcRelVar 0.945926
tremorPcX 0.764707
tremorPcY -0.644378

Circle Segment 1

Duration 13.64 s, Accuracy Estimate 2.674 (lower is better)

Circle Segment 2

Duration 9.52 s, Accuracy Estimate 1.603 (lower is better)

Circle Segment 3

Duration 10.08 s, Accuracy Estimate 1.177 (lower is better)

Circle Segment 4

Duration 10.2 s, Accuracy Estimate 1.321 (lower is better)

Circle Segment 5

Duration 9.36 s, Accuracy Estimate 1.401 (lower is better)

Circle Segment 6

Duration 9.8 s, Accuracy Estimate 1.234 (lower is better)

Circle Segment 7

Duration 8.2 s, Accuracy Estimate 1.278 (lower is better)

Circle Segment 8

Duration 9.44 s, Accuracy Estimate 1.247 (lower is better)

Circle Segment 9

Duration 9.56 s, Accuracy Estimate 1.493 (lower is better)

Circle Segment 10

Duration 11.36 s, Accuracy Estimate 1.933 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 23.8
timePerSpiralCoV 0.207871
timePerSpiralSlope -0.0177031
meanError 2.05119
tremorFreq 5.07812
tremorRelPower 51.4464
tremorGyroAmpMean 0.0296036
tremorGyroAmpSlope 0.00182911
tremorGyroAmpCoV 0.440981
tremorCoordAmpMean 0.0884123
tremorCoordAmpSlope 0.00189374
tremorCoordAmpCoV 0.539407
tremorAccAmpMean 0.0777883
tremorAccAmpSlope 0.000880473
tremorAccAmpCoV 0.531562
tremorPcRelVar 0.824997
tremorPcX -0.792773
tremorPcY -0.609517

Spiral Segment 1

Duration 28.32 s, Accuracy Estimate 2.068 (lower is better)

Spiral Segment 2

Duration 25.44 s, Accuracy Estimate 1.971 (lower is better)

Spiral Segment 3

Duration 25.4 s, Accuracy Estimate 1.668 (lower is better)

Spiral Segment 4

Duration 26.88 s, Accuracy Estimate 1.789 (lower is better)

Spiral Segment 5

Duration 19.84 s, Accuracy Estimate 2.188 (lower is better)

Spiral Segment 6

Duration 25.04 s, Accuracy Estimate 2.178 (lower is better)

Spiral Segment 7

Duration 17.12 s, Accuracy Estimate 1.958 (lower is better)

Spiral Segment 8

Duration 19.88 s, Accuracy Estimate 2.339 (lower is better)

Spiral Segment 9

Duration 17.8 s, Accuracy Estimate 1.921 (lower is better)

Spiral Segment 10

Duration 32.28 s, Accuracy Estimate 2.431 (lower is better)

Elel

eDurationMean 0.488462
eDurationStd 0.153398
eDurationStdnorm 0.314043
eDurationMedian 0.47
eDurationQuartdelta 0.16
eDurationQuartdeltanorm 0.340426
eDurationKurt 5.87553
eDurationTrenddiff -0.1
eDurationTrendratio 0.80198
eWidthMean 5.65035
eWidthStd 1.96213
eWidthStdnorm 0.347259
eWidthMedian 5.265
eWidthQuartdelta 2.20697
eWidthQuartdeltanorm 0.419178
eWidthKurt 5.3935
eWidthTrenddiff -1.52113
eWidthTrendratio 0.756994
eHeightMean 7.55706
eHeightStd 2.17602
eHeightStdnorm 0.287945
eHeightMedian 7.137
eHeightQuartdelta 2.58168
eHeightQuartdeltanorm 0.361731
eHeightKurt 4.30116
eHeightTrenddiff -1.17664
eHeightTrendratio 0.846788
eAspectMean 0.752367
eAspectStd 0.165225
eAspectStdnorm 0.219607
eAspectMedian 0.713597
eAspectQuartdelta 0.264767
eAspectQuartdeltanorm 0.371031
eAspectKurt 2.36161
eAspectTrenddiff -0.144352
eAspectTrendratio 0.821837
eSlantMean 0.140226
eSlantStd 0.241267
eSlantStdnorm 1.72056
eSlantMedian 0.162939
eSlantQuartdelta 0.357444
eSlantQuartdeltanorm 2.19373
eSlantKurt 2.43626
eSlantTrenddiff -0.313321
eRtopMean 0.768962
eRtopStd 0.118654
eRtopStdnorm 0.154304
eRtopMedian 0.761855
eRtopQuartdelta 0.172081
eRtopQuartdeltanorm 0.225871
eRtopKurt 2.79569
eRtopTrenddiff -0.0184107
eRbotMean 0.600947
eRbotStd 0.245659
eRbotStdnorm 0.408787
eRbotMedian 0.587166
eRbotQuartdelta 0.364962
eRbotQuartdeltanorm 0.621565
eRbotKurt 2.60774
eRbotTrenddiff 0.302702
eRrightMean 0.838262
eRrightStd 0.0722063
eRrightStdnorm 0.0861381
eRrightMedian 0.830982
eRrightQuartdelta 0.112797
eRrightQuartdeltanorm 0.135739
eRrightKurt 2.34631
eRrightTrenddiff 0.0242371
eRleftMean 0.371548
eRleftStd 0.12077
eRleftStdnorm 0.325045
eRleftMedian 0.38946
eRleftQuartdelta 0.204463
eRleftQuartdeltanorm 0.52499
eRleftKurt 2.16665
eRleftTrenddiff 0.140946
lDurationMean 0.6648
lDurationStd 0.217342
lDurationStdnorm 0.326929
lDurationMedian 0.6425
lDurationQuartdelta 0.305
lDurationQuartdeltanorm 0.474708
lDurationKurt 3.20183
lDurationTrenddiff -0.23
lDurationTrendratio 0.689189
lWidthMean 10.7654
lWidthStd 3.07787
lWidthStdnorm 0.285905
lWidthMedian 10.3545
lWidthQuartdelta 4.46389
lWidthQuartdeltanorm 0.431106
lWidthKurt 3.34739
lWidthTrenddiff -3.99589
lWidthTrendratio 0.695479
lHeightMean 19.4509
lHeightStd 3.68045
lHeightStdnorm 0.189217
lHeightMedian 19.0125
lHeightQuartdelta 3.37154
lHeightQuartdeltanorm 0.177333
lHeightKurt 15.4942
lHeightTrenddiff -2.63986
lHeightTrendratio 0.869579
lAspectMean 0.551829
lAspectStd 0.117235
lAspectStdnorm 0.212447
lAspectMedian 0.559468
lAspectQuartdelta 0.163097
lAspectQuartdeltanorm 0.291521
lAspectKurt 2.44755
lAspectTrenddiff -0.129768
lAspectTrendratio 0.79505
lSlantMean 0.21649
lSlantStd 0.171871
lSlantStdnorm 0.793901
lSlantMedian 0.176018
lSlantQuartdelta 0.250575
lSlantQuartdeltanorm 1.42358
lSlantKurt 2.33516
lSlantTrenddiff -0.224131
lRtopMean 0.786627
lRtopStd 0.123814
lRtopStdnorm 0.157399
lRtopMedian 0.797222
lRtopQuartdelta 0.213142
lRtopQuartdeltanorm 0.267356
lRtopKurt 2.12061
lRtopTrenddiff -0.124097
lRbotMean 0.424542
lRbotStd 0.183946
lRbotStdnorm 0.433282
lRbotMedian 0.417578
lRbotQuartdelta 0.236786
lRbotQuartdeltanorm 0.567047
lRbotKurt 3.77213
lRbotTrenddiff 0.232843
lRrightMean 0.882541
lRrightStd 0.0671132
lRrightStdnorm 0.0760454
lRrightMedian 0.879488
lRrightQuartdelta 0.112394
lRrightQuartdeltanorm 0.127794
lRrightKurt 2.58821
lRrightTrenddiff -0.035025
lRleftMean 0.246685
lRleftStd 0.117401
lRleftStdnorm 0.475916
lRleftMedian 0.222836
lRleftQuartdelta 0.165444
lRleftQuartdeltanorm 0.742449
lRleftKurt 4.28001
lRleftTrenddiff 0.13906

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

Elel Segment 13

FITTS Short Modified

meanTouchScore 0.724999
sumTouchScores 23.2
meanMovementTime 0.571935
numTouches 32
undershootPercentage 9.375
overshootPercentage 25

fitts_short data not in signals file.

FITTS Long Modified

meanTouchScore 0.569469
sumTouchScores 8.54203
meanMovementTime 0.888571
numTouches 15
undershootPercentage 6.66667
overshootPercentage 60

fitts_long data not in signals file.

ZigZag

numZigzags 5
timePerZigzagMean 13.336
timePerZigzagCoV 0.169016
timePerZigzagSlope -0.084883
meanError 2.5943
tremorFreq 6.15234
tremorRelPower 40.3592
tremorGyroAmpMean 0.0633996
tremorGyroAmpSlope -0.00584415
tremorGyroAmpCoV 0.356417
tremorCoordAmpMean 0.150986
tremorCoordAmpSlope 0.00597451
tremorCoordAmpCoV 0.337713
tremorAccAmpMean 0.124789
tremorAccAmpSlope 0.000184957
tremorAccAmpCoV 0.230539
tremorPcRelVar 0.695033
tremorPcX 0.315717
tremorPcY -0.948853

ZigZag Segment 1

Duration 17.32 s, Accuracy Estimate 2.31 (lower is better)

ZigZag Segment 2

Duration 12.68 s, Accuracy Estimate 2.757 (lower is better)

ZigZag Segment 3

Duration 12.44 s, Accuracy Estimate 3.032 (lower is better)

ZigZag Segment 4

Duration 12.48 s, Accuracy Estimate 2.572 (lower is better)

ZigZag Segment 5

Duration 11.76 s, Accuracy Estimate 2.302 (lower is better)

ZigZag Offset

numZigzags 6
timePerZigzagMean 14.6933
timePerZigzagCoV 0.121278
timePerZigzagSlope -0.054602
zigzagHeightMean 84.8379
zigzagHeightCoV 0.119332
zigzagHeightSlope 0.0350426
meanError 0.0411884
tremorFreq 5.95703
tremorRelPower 29.3256
tremorGyroAmpMean 0.0492206
tremorGyroAmpSlope -0.000779372
tremorGyroAmpCoV 0.245196
tremorCoordAmpMean 0.132317
tremorCoordAmpSlope -0.000531504
tremorCoordAmpCoV 0.355715
tremorAccAmpMean 0.0939427
tremorAccAmpSlope -0.000790923
tremorAccAmpCoV 0.335584
tremorPcRelVar 0.757806
tremorPcX 0.0229907
tremorPcY 0.999736

ZigZag Offset Segment 1

Duration 17.28 s, Accuracy Estimate 0.056 (lower is better)

ZigZag Offset Segment 2

Duration 16.6 s, Accuracy Estimate 0.037 (lower is better)

ZigZag Offset Segment 3

Duration 13.36 s, Accuracy Estimate 0.03 (lower is better)

ZigZag Offset Segment 4

Duration 13.76 s, Accuracy Estimate 0.034 (lower is better)

ZigZag Offset Segment 5

Duration 14.04 s, Accuracy Estimate 0.032 (lower is better)

ZigZag Offset Segment 6

Duration 13.12 s, Accuracy Estimate 0.059 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.85}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.6}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.8565636083380892}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8960195613637689}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.44192353540889495}